Background: Presynaptic forms of congenital myasthenic syndromes (CMS) due to pathogenic variants in SLC18A3 impairing the synthesis and recycling of acetylcholine (ACh) have recently been described.SLC18A3 encodes the vesicular ACh transporter (VAChT), modulating the active transport of ACh at the neuromuscular junction, and homozygous loss of VAC
Recently, due to the changing geopolitical situation, economic instability and vulnerability, practicing auditors are facing new challenges that affect the identification and assessment of risks of material misstatement of financial statements.The purpose of the research is to identify the main factors affecting the risk of material misstatement an
The objective of this study was to identify relevant descriptors of ruminal pH post-prandial evolution that can replace the mean pH (considered unsatisfactory).These descriptors are to be used in the attempts to predict ruminal pH from dietary characteristics, in order to quantify the potential of a diet to induce subacute ruminal acidosis from its
Prior studies have suggested the possibility of immune-mediated death of xenogeneic hepatocytes in a bioartificial liver (BAL) during hemoperfusion.This study was designed to elucidate how immunity may cause death of xenogeneic hepatocytes in the BAL.Healthy dogs were treated with a BAL containing hollow fiber membranes with large pores (200 nm) or
Artwork Objective Septic liver injury is a major burden for the clinical management of sepsis.Hepatocyte cell death plays a crucial pathophysiological role in sepsis.A recent study proposed that NLRP3 inflammasome-mediated pyroptosis participates in septic liver injury.Therefore, investigating the mechanism controlling this process may help manage